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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RET
All Species:
9.09
Human Site:
Y1062
Identified Species:
18.18
UniProt:
P07949
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P07949
NP_065681.1
1114
124319
Y1062
T
W
I
E
N
K
L
Y
G
M
S
D
P
N
W
Chimpanzee
Pan troglodytes
XP_001171246
813
90715
M762
Q
E
Y
L
D
L
S
M
P
L
D
Q
Y
S
P
Rhesus Macaque
Macaca mulatta
XP_001090823
731
81824
M680
Q
E
Y
L
D
L
S
M
P
L
D
Q
Y
S
P
Dog
Lupus familis
XP_543915
1108
124018
Y1056
T
W
I
E
N
K
L
Y
G
M
S
D
P
N
W
Cat
Felis silvestris
Mouse
Mus musculus
P35546
1115
123855
Y1063
T
W
I
E
N
K
L
Y
G
M
S
D
P
N
W
Rat
Rattus norvegicus
Q04589
822
91806
M771
Q
E
Y
L
D
L
S
M
P
L
D
Q
D
S
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507715
665
75620
G614
W
I
E
N
K
L
Y
G
M
S
Y
P
N
W
P
Chicken
Gallus gallus
P18461
823
92281
L772
L
T
T
N
E
E
Y
L
D
L
S
G
P
L
E
Frog
Xenopus laevis
Q03364
813
91322
L762
T
N
E
E
Y
L
D
L
S
A
P
L
E
Q
Y
Zebra Danio
Brachydanio rerio
Q8JG38
817
91370
L766
L
A
T
N
E
E
Y
L
D
L
C
A
P
V
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q09147
1052
117795
Q1001
E
S
F
D
G
I
L
Q
Q
A
S
S
N
P
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Q26614
972
110463
N921
R
I
I
S
V
S
S
N
Q
D
Y
L
D
L
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
28.4
27.9
86.4
N.A.
83.4
28.9
N.A.
43
27.5
28.1
27.7
N.A.
23.6
N.A.
N.A.
24
Protein Similarity:
100
42.2
41.5
92
N.A.
90.2
43
N.A.
50.5
43.5
42.3
42
N.A.
37.7
N.A.
N.A.
41.2
P-Site Identity:
100
0
0
100
N.A.
100
0
N.A.
0
13.3
13.3
6.6
N.A.
13.3
N.A.
N.A.
6.6
P-Site Similarity:
100
20
20
100
N.A.
100
20
N.A.
0
26.6
20
20
N.A.
20
N.A.
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
0
0
0
0
0
0
17
0
9
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% C
% Asp:
0
0
0
9
25
0
9
0
17
9
25
25
17
0
0
% D
% Glu:
9
25
17
34
17
17
0
0
0
0
0
0
9
0
25
% E
% Phe:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
9
0
0
9
25
0
0
9
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
17
34
0
0
9
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
9
25
0
0
0
0
0
0
0
0
0
% K
% Leu:
17
0
0
25
0
42
34
25
0
42
0
17
0
17
0
% L
% Met:
0
0
0
0
0
0
0
25
9
25
0
0
0
0
0
% M
% Asn:
0
9
0
25
25
0
0
9
0
0
0
0
17
25
9
% N
% Pro:
0
0
0
0
0
0
0
0
25
0
9
9
42
9
34
% P
% Gln:
25
0
0
0
0
0
0
9
17
0
0
25
0
9
0
% Q
% Arg:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
9
0
9
0
9
34
0
9
9
42
9
0
25
0
% S
% Thr:
34
9
17
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
9
0
0
0
0
0
0
0
0
9
0
% V
% Trp:
9
25
0
0
0
0
0
0
0
0
0
0
0
9
25
% W
% Tyr:
0
0
25
0
9
0
25
25
0
0
17
0
17
0
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _